AMPLIFYING EVOLUTION ACROSS A SPECTRUM OF MICROBIAL SPECIES AND TRAITS

At Evolutor, coupling our in-house microbiological toolkit with our Accelerated Evolution Platform approach means that we can tap into the hidden genetic potential of microbial strains to rapidly optimise selected traits.

Here, a strain was optimised to significantly improve its thermotolerance at 46ºC. The evolved improvements were then reverse engineered to identify the genetic changes responsible. These changes were non-intuitive and could not have been achieved using a rational synthetic biology approach.

For more information or to download our white paper on thermotolerance, please use the form below.

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Many large scale precision fermentation processes involve the production or presence of compounds that can be toxic or inhibitive to the microbial strain being grown.

At Evolutor, we have used our platform to develop high performance yeast strains capable of operating in increased concentrations of chemical inhibitors. This trait is vital for improving the productivity of bio-manufacturing processes.

For more information or to download our white paper on inhibitor tolerance, please use the form below.

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Feedstock selection is a key factor impacting the commercial viability and supply chain security of a bio-manufacturing production process. At Evolutor, we deploy laser-focused evolutionary regimes to unlock the use of new feedstocks and increase the feedstock flexibility of bio-manufacturing strains.

In this demonstration case, we developed novel bacterial strains that can capture a range of industrial wastes as growth substrates, as well as tolerate common inhibitors found in several widely-used feedstocks.

For more information or to download our white paper about feedstock utilisation, please use the form below.

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